The start of a new Administration and a new Congress provides a vital opportunity to dramatically scale up the U.S. response to climate change. The Center for Climate and Energy Solutions has worked closely with leading companies to assess policy options for decarbonizing the U.S. economy. Drawing on these discussions, this policy brief recommends a comprehensive set of policy priorities to drive climate innovation, reduce emissions, strengthen climate resilience, remedy inequities and—in many cases—support the post-pandemic economic recovery. Taken together, these steps would establish the essential foundations of an ambitious, just, durable, bipartisan climate policy putting the United States on the path toward carbon neutrality.