Climate change is a multi-faceted challenge that is intrinsically connected to a broad range of other issue areas, and it must be addressed on multiple fronts. In considering the global response to climate change post-2020, it is important to consider not only the central role of the United Nations Framework Convention on Climate Change (UNFCCC), but also the potential roles of other international regimes and initiatives, and links among them. This paper provides a brief overview of relevant non-UNFCCC venues and suggests some broad issues for policymakers.